1\u3001 Appearance and Form
At room temperature (20 \u2103): colorless to light yellow transparent oily liquid; The viscosity increases at low temperatures, and if the temperature continues to decrease, it will thicken, but the melting point is low and it will not easily solidify
Melting point: -15 \u2103
2\u3001 Basic physical constants (commonly used in industry\/pharmacopoeia)
-Relative density (17 \u2103): 0.9221 g\/cm \u00b3, lighter than water
-Refractive index \\ (d_D ^ {17} ): 1.477~1.481 (an important indicator for GC detection)
-Boiling point: atmospheric pressure 328 \u2103; Reduced pressure at 130 \u2103\/0.5 Torr (high boiling point, must be purified by vacuum distillation)
-Flash point: 145.3 \u2103, belongs to high flash point flammable liquid, not easy to flash and explode
-Vapor pressure: extremely low (about 0.04 Pa at 25 \u2103) \u2192 weak volatility, long-lasting fragrance, typical feature of macrocyclic musk
-Oil water partition coefficient LogP \u2248 5.28, strongly lipophilic, almost insoluble in water
3\u3001 Solubility performance
-Water: extremely slightly soluble, with a solubility of only a few hundred \u03bc g\/L in water at 20 \u2103, and basically insoluble in the aqueous phase
-Organic solvents: soluble in ethanol, ether, acetone, chloroform, oils, and mineral oils; Soluble in methanol (slightly soluble)
4\u3001 Chemical stability
a. Functional group: Fifteen membered macrocyclic ketone, with only one ketone carbonyl group and no easily oxidizable double bond
-Resistant to weak acids and weak bases, stable at room temperature; Long term heating of strong bases can lead to ketogenic decomposition
-Not easily oxidized at room temperature, more stable than polycyclic musk, and also biodegradable
b. Chiral stability: Under conventional storage conditions, the chiral configuration is stable and not easily racemized; Configuration transformation can only occur in high temperature and strong acid-base environments, resulting in the loss of medicinal\/natural aroma value
c. No aggregation occurs; No risk of self reaction
5\u3001 Molecular polarity and chromatographic characteristics
-Topological polarity surface area PSA: 17.07, very low polarity, belonging to weakly polar compounds
-GC gas chromatography: peaks appear on non-polar chromatography columns, and GC is commonly used in pharmacopoeia to determine content and optical purity; Can distinguish left\/right isomers through chiral chromatography columns
6\u3001 Storage related physical and chemical tips
-Sealed, dark, and cool storage; Light exposure and high temperature will slowly oxidize and change color (yellowing and deepening)
-Long term exposure to strong oxidants and concentrated alkalis is not recommended
-Low temperature storage leads to an increase in viscosity, but upon heating up, it returns to fluidity, which is a normal physical phenomenon and does not affect the quality<\/p>","protected":false},"excerpt":{"rendered":"
1\u3001 Appearance and FormAt room temperature (20 \u2103): colorless to light yellow transparent oily liquid; The viscosity increases at low temperatures, and if the temperature continues to decrease, it will thicken, but the melting point is low and it will not easily solidifyMelting point: -15 \u21032\u3001 Basic physical constants (commonly used in industry\/pharmacopoeia)-Relative density (17 \u2103): 0.9221 g\/cm \u00b3, lighter than water-Refractive index \\ (d_D ^ {17} ): 1.477~1.481 (an important indicator for GC detection)-Boiling […]<\/p>\n","protected":false},"author":1,"featured_media":364,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[18],"tags":[],"class_list":["post-660","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/celsivita.com\/ko\/wp-json\/wp\/v2\/posts\/660","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/celsivita.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/celsivita.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/celsivita.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/celsivita.com\/ko\/wp-json\/wp\/v2\/comments?post=660"}],"version-history":[{"count":1,"href":"https:\/\/celsivita.com\/ko\/wp-json\/wp\/v2\/posts\/660\/revisions"}],"predecessor-version":[{"id":661,"href":"https:\/\/celsivita.com\/ko\/wp-json\/wp\/v2\/posts\/660\/revisions\/661"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/celsivita.com\/ko\/wp-json\/wp\/v2\/media\/364"}],"wp:attachment":[{"href":"https:\/\/celsivita.com\/ko\/wp-json\/wp\/v2\/media?parent=660"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/celsivita.com\/ko\/wp-json\/wp\/v2\/categories?post=660"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/celsivita.com\/ko\/wp-json\/wp\/v2\/tags?post=660"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}