1、 Characteristics of Pharmaceutical API Applications
a. Efficacy matching natural musk: Levothyrone is the active chiral monomer in natural musk, which is the core raw material of artificial musk and meets pharmacopoeia standards. It can replace natural musk in compliance and protect wild musk resources.
b. Fat soluble advantages of suitable formulations: high LogP, easy to penetrate biological membranes, suitable for making fat soluble traditional Chinese medicine formulations such as tinctures, ointments, drop pills, aerosols, etc; Poor water solubility, water needle system requires solubilizing technology.
c. Clear pharmacological effects: aromatic opening of orifices, promoting blood circulation and meridian circulation, and dilating coronary arteries; Low dose excitation center, high-dose inhibition center; Has anti-inflammatory, anti-inflammatory, and pain relieving effects. The formula must be labeled as prohibited for pregnant women as it has uterine stimulating effects.
d. High quality control threshold: Pharmaceutical grade has strict indicators for optical purity, chiral content, impurities, and GC purity, and COA and pharmacopoeia testing reports must be provided; High temperature/strong alkali will cause racemization, and the processing technology should not use high temperature and strong alkali, otherwise the efficacy will decrease and it does not comply with the pharmacopoeia.
e. Low addition amount: the addition amount in traditional Chinese patent medicines and simple preparations formula is very small, and a small amount can take effect.
2、 Application characteristics of high-end daily chemical essence
a. Strong natural feeling, it is the preferred raw material for replicating natural musk: the aroma is close to natural musk, warm animal fragrance+delicate powdery feeling, without the rough soap like texture of nitro musk and polycyclic musk.
b. Super strong aroma setting+blending and enhancing effect: The aroma threshold is extremely low, and even trace amounts can play a role; Can be used as a base fragrance, blending floral, woody, and amber aromas to enhance the overall aroma level and skin feel; The fragrance stick can last for more than two weeks in Firmenich.
c. Good compatibility with the formula: excellent compatibility with the vast majority of fragrance ingredients; Recommended for advanced perfume, ointment and high-end fragrance; It can also be used in a small amount in soap and lotion essence.
-Recommended dosage of perfume: 0.1%~2%; Minor additions (<0.5%) are generally used for washing and care products
d. Safety and environmental advantages: large ring structure, biodegradable; Unlike nitromusk and polycyclic musk, which have environmental accumulation problems.
e. Short board: high price, only used for high-end essence; Ordinary affordable daily chemical products generally use racemic musk ketone or other synthetic musk as a substitute.
3、 Common characteristics of practical processing applications
a. Feeding characteristics: oily liquid, directly soluble in oil and ethanol systems; The aqueous system requires emulsification/co solvents and is not directly soluble in water.
b. Processing temperature limitation: Although the boiling point is high, there is a risk of slow oxidation and chiral racemization due to prolonged high temperatures; The temperature of concentration and distillation processes should not be too high.
c. The impact of storage on finished products: If the finished product system is stored under strong light and high temperature for a long time, it will cause slow oxidation of levomuscone, resulting in yellowing of color and deterioration of aroma; It is recommended to store finished products containing this raw material away from light.
d. Detection and differentiation: Fragrance level depends on aroma, GC purity; Medicinal APIs must undergo additional optical purity testing to distinguish between left-handed and racemic forms.
