1、 Appearance and Form
At room temperature (20 ℃): colorless to light yellow transparent oily liquid; The viscosity increases at low temperatures, and if the temperature continues to decrease, it will thicken, but the melting point is low and it will not easily solidify
Melting point: -15 ℃
2、 Basic physical constants (commonly used in industry/pharmacopoeia)
-Relative density (17 ℃): 0.9221 g/cm ³, lighter than water
-Refractive index \ (d_D ^ {17} ): 1.477~1.481 (an important indicator for GC detection)
-Boiling point: atmospheric pressure 328 ℃; Reduced pressure at 130 ℃/0.5 Torr (high boiling point, must be purified by vacuum distillation)
-Flash point: 145.3 ℃, belongs to high flash point flammable liquid, not easy to flash and explode
-Vapor pressure: extremely low (about 0.04 Pa at 25 ℃) → weak volatility, long-lasting fragrance, typical feature of macrocyclic musk
-Oil water partition coefficient LogP ≈ 5.28, strongly lipophilic, almost insoluble in water
3、 Solubility performance
-Water: extremely slightly soluble, with a solubility of only a few hundred μ g/L in water at 20 ℃, and basically insoluble in the aqueous phase
-Organic solvents: soluble in ethanol, ether, acetone, chloroform, oils, and mineral oils; Soluble in methanol (slightly soluble)
4、 Chemical stability
a. Functional group: Fifteen membered macrocyclic ketone, with only one ketone carbonyl group and no easily oxidizable double bond
-Resistant to weak acids and weak bases, stable at room temperature; Long term heating of strong bases can lead to ketogenic decomposition
-Not easily oxidized at room temperature, more stable than polycyclic musk, and also biodegradable
b. Chiral stability: Under conventional storage conditions, the chiral configuration is stable and not easily racemized; Configuration transformation can only occur in high temperature and strong acid-base environments, resulting in the loss of medicinal/natural aroma value
c. No aggregation occurs; No risk of self reaction
5、 Molecular polarity and chromatographic characteristics
-Topological polarity surface area PSA: 17.07, very low polarity, belonging to weakly polar compounds
-GC gas chromatography: peaks appear on non-polar chromatography columns, and GC is commonly used in pharmacopoeia to determine content and optical purity; Can distinguish left/right isomers through chiral chromatography columns
6、 Storage related physical and chemical tips
-Sealed, dark, and cool storage; Light exposure and high temperature will slowly oxidize and change color (yellowing and deepening)
-Long term exposure to strong oxidants and concentrated alkalis is not recommended
-Low temperature storage leads to an increase in viscosity, but upon heating up, it returns to fluidity, which is a normal physical phenomenon and does not affect the quality
